Validating targets antiparasitic chemotherapy

If this is a republication request please include details of the new work in which the Wiley content will appear.Received Date: October 31, 2015 Accepted Date: November 24, 2015 Published Date: November 30, 2015 Citation: Nigussie D, Beyene T, Shah NA, Belew S (2015) New Targets in Malaria Parasite Chemotherapy: A Review. doi:10.4172/2470-6965.1000S1-007 Copyright: © 2015 Nigussie D, et al.

This premise is validated by the tendency of current anthelmintics to act on classical neurotransmitter-gated ion channels present on helminth nerve and/or muscle, yielding therapeutic endpoints associated with paralysis and/or death.Addressing parasitic diseases and those caused by bacteria, this much needed reference and handbook provides a unique insight into the approach adopted by commercial science towards infectious diseases, including the work of medicinal chemists.Many of the authors are scientists with hands-on experience of drug discovery units within the pharmaceutical industry.Address correspondence to this author at the Drug Discovery Unit, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK; Tel: (44)1382 385155; Fax: (44)1382 385542; E-mail: [email protected] This is an open access article distributed under the terms of the Creative Commons Attribution License ( which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.The discovery of drugs is a lengthy, high-risk and expensive business taking at least 12 years and is estimated to cost upwards of US0 million for each drug to be successfully approved for clinical use.

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Modern advancement in the biology of the parasite and different genomic techniques provide wide ranges of novel targets in the development of new therapy.

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