Validating targets antiparasitic chemotherapy
If this is a republication request please include details of the new work in which the Wiley content will appear.Received Date: October 31, 2015 Accepted Date: November 24, 2015 Published Date: November 30, 2015 Citation: Nigussie D, Beyene T, Shah NA, Belew S (2015) New Targets in Malaria Parasite Chemotherapy: A Review. doi:10.4172/2470-6965.1000S1-007 Copyright: © 2015 Nigussie D, et al.
This premise is validated by the tendency of current anthelmintics to act on classical neurotransmitter-gated ion channels present on helminth nerve and/or muscle, yielding therapeutic endpoints associated with paralysis and/or death.Addressing parasitic diseases and those caused by bacteria, this much needed reference and handbook provides a unique insight into the approach adopted by commercial science towards infectious diseases, including the work of medicinal chemists.Many of the authors are scientists with hands-on experience of drug discovery units within the pharmaceutical industry.Address correspondence to this author at the Drug Discovery Unit, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK; Tel: (44)1382 385155; Fax: (44)1382 385542; E-mail: [email protected] This is an open access article distributed under the terms of the Creative Commons Attribution License ( which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.The discovery of drugs is a lengthy, high-risk and expensive business taking at least 12 years and is estimated to cost upwards of US0 million for each drug to be successfully approved for clinical use.
Search for validating targets antiparasitic chemotherapy:
Modern advancement in the biology of the parasite and different genomic techniques provide wide ranges of novel targets in the development of new therapy.